Preheat oven to 325°F. Combine rub ingredients in small bowl; press evenly onto all surfaces of beef Roast.
Place roast on rack in shallow roasting pan. Insert ovenproof meat thermometer so tip is centered in thickest part of beef. Do not add water or cover. Roast in 325°F oven 1-1/4 to 1-3/4 hours for medium rare doneness.
Remove roast when meat thermometer registers 135°F for medium rare. Transfer roast to carving board; tent loosely with aluminum foil. Let stand 15 to 20 minutes. (Temperature will continue to rise about 10°F to reach 145°F for medium rare.)
Carve roast into thin slices; season with salt and black pepper, as desired.
Nutrition information per serving: 158 Calories; 45 kcal Calories from fat; 5 g Total Fat; 2 g Saturated Fat; 2 g Monounsaturated Fat; 71 mg Cholesterol; 83 mg Sodium; 0 g Total Carbohydrate; 0 g Dietary Fiber; 27 g Protein; 2.6 mg Iron; 7.9 mg Niacin; 0.4 mg Vitamin B6; 1.5 mcg Vitamin B12; 4.7 mg Zinc; 31 mcg Selenium; 103.3 mg Choline;