Preheat a large cast iron skillet over high heat. Shape Ground Beef into four ¾-inch thick patties. Season with salt and pepper on each side. Make a small indention in the center of the burger with your thumb. Press one portion of shredded Brisket into each burger patty.
Place each patty in the skillet, Brisket side down, cooking for about 4 minutes on each side, flipping once, until the internal temperature of the patties reach 160℉.
Place burgers on buns. Top burgers with cheese and desired toppings.
Nutrition information per serving: 540 Calories; 240 Calories from fat; 26.7 g Total Fat (11.6 g Saturated Fat; 4.7 g Monounsaturated Fat); 142 mg Cholesterol; 684.1 mg Sodium; 21.8 g Total Carbohydrate; 2 g Dietary Fiber; 47.2 g Protein; 3.8 mg Iron; 434.6 mg Potassium; 0.1 mg Thiamin; 0.3 mg Riboflavin; 8.9 mg Niacin (NE); 0.5 mg Vitamin B6; 2.8 mcg Vitamin B12; 6.1 mg Zinc; 23.5 mcg Selenium; 84.5 mg Choline.
This recipe is an excellent source of Protein, Niacin, Vitamin B6, Vitamin B12, Iron, Phosphorus, Selenium, and Zinc. It is a good source of Riboflavin and Choline.