Combine Ground Beef, 1 teaspoon garlic powder, 1 teaspoon onion powder, 1/2 teaspoon rubbed sage, 1/2 teaspoon salt and crushed red pepper in large bowl, mixing lightly but thoroughly. Heat large nonstick skillet over medium heat until hot. Add beef mixture; cook 8 to 10 minutes, breaking into 1/2-inch crumbles and stirring occasionally. Remove beef mixture from skillet with slotted spoon into large bowl; set aside.
Preheat oven to 350°F. In same skillet, heat butter on medium heat until hot. Add leeks, cook and stir 5 minutes. Add leeks to beef mixture. Stir in bread cubes, broth, apples, cranberries, remaining 1 teaspoon garlic powder, remaining 1 teaspoon onion powder, remaining 1-1/2 teaspoons rubbed sage and remaining 1 teaspoon salt to beef mixture.
Spray 9 x 13-inch baking dish with cooking spray. Place beef mixture into prepared dish; cover with aluminum foil. Bake in 350°F oven 30 to 40 minutes until heated through.
Nutrition information per serving: 291 Calories; 63 kcal Calories from fat; 7 g Total Fat; 3 g Saturated Fat; 2 g Monounsaturated Fat; 41 mg Cholesterol; 971 mg Sodium; 43 g Total Carbohydrate; 2.9 g Dietary Fiber; 15 g Protein; 3 mg Iron; 4.7 mg Niacin; 0.3 mg Vitamin B6; 1.1 mcg Vitamin B12; 3 mg Zinc; 25.2 mcg Selenium; 46.7 mg Choline;